Safety Evaluation of Polyethylene Terephthalate Resins (I)

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  • ポリエチレンテレフタレート樹脂の安全性に関する研究 (第1報)
  • ポリエチレン テレフタレート ジュシ ノ アンゼンセイ ニカンスルケンキュウ
  • Studies on the Acute and Subacute (3 Months) Toxicities by the Oral Administration in Rats
  • ラットでの経口投与による急性および亜急性 (3か月) 毒性試験

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Acute and subacute (3 months) toxicities of chloroform extracts of polyethylene terephthalate (PET) resins catalyzed by titanium or germanium were studied in rats by the oral administration. The following results were obtained.<br>1) By the single oral administration, the PET-extracts did not show any toxic signs during 7 days even at the largest dose of technical permittance, 10g/kg.<br>2) By the oral administration (PET-Ti: 5, 30, 180 and 400mg/kg/day, PET-Ge: 5, 30 and 180mg/kg/day) for 3 months, no remarkable changes were observed in general behavior, body weight, food intake, serum biochemical and hematological findings, urinalysis and organ weights.<br>It is concluded that chloroform extracts from PET resins do not have any toxic effect on rats under the experimental conditions.

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