グリチルリチン酸ニナトリウムのラットにおける胎仔毒性

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書誌事項

タイトル別名
  • Effect of Disodium Glycyrrhizinate on Pregnant Rats and Their Offspring
  • グリチルリチンサン 2 ナトリウム ラット ニ オケル タイシ ドクセイ エイ
  • Studies on the Fetal Toxicity of Food Additives. III
  • 食品添加物の胎仔毒性に関する研究 (III)

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説明

The teratogenicity of disodium glycyrrhizinate (NaG) was examined in Wistar rats. Pregnant rats were fed diet containing 2%, 0.4% or 0.08% NaG ad libitum from day 0 to 20 of pregnancy. A comparison of the control and all groups of rats treated with NaG revealed no significant differences in food intake and in body weight gain during pregnancy. However, body weight gains after delivery were significantly lower in the two highest level groups. No significant differences between the control and NaG-treated groups were found in the numbers of corpora lutea and implants of dams, in the number of live fetuses and intrauterine dead fetuses per litter, in the sex ratios, in fetal body weight of both sexes, in the placental weight, in the degrees of ossification in the sternebrae and caudal vertebrae of the fetuses, or in the live birth index, survival rate or body weight gain of the offspring within 8 weeks after birth. Several kinds of skeletal variation of the fetus were observed in all the groups treated with NaG, but the incidences showed no significant differences as compared with the control. Except for one fetus with dilatation of the renal pelvis in the 0.08% group, no fetus with external, skeletal or internal malformations was found at any level examined. From these results, it can be concluded that NaG has no teratogenic effects on the fetus in rats.

収録刊行物

  • 食品衛生学雑誌

    食品衛生学雑誌 26 (5), 460-464_1, 1985

    公益社団法人 日本食品衛生学会

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