A 52-Week Feeding Study of Genetically Modified Soybeans in F344 Rats

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  • SAKAMOTO Yoshimitsu
    Department of Environmental Health and Toxicology, Tokyo Metropolitan Institute of Public Health
  • TADA Yukie
    Department of Environmental Health and Toxicology, Tokyo Metropolitan Institute of Public Health
  • FUKUMORI Nobutaka
    Department of Environmental Health and Toxicology, Tokyo Metropolitan Institute of Public Health
  • TAYAMA Kuniaki
    Department of Environmental Health and Toxicology, Tokyo Metropolitan Institute of Public Health
  • ANDO Hiroshi
    Department of Environmental Health and Toxicology, Tokyo Metropolitan Institute of Public Health
  • TAKAHASHI Hiroshi
    Department of Environmental Health and Toxicology, Tokyo Metropolitan Institute of Public Health
  • KUBO Yoshikazu
    Department of Environmental Health and Toxicology, Tokyo Metropolitan Institute of Public Health
  • NAGASAWA Akemichi
    Department of Environmental Health and Toxicology, Tokyo Metropolitan Institute of Public Health
  • YANO Norio
    Department of Environmental Health and Toxicology, Tokyo Metropolitan Institute of Public Health
  • YUZAWA Katsuhiro
    Department of Environmental Health and Toxicology, Tokyo Metropolitan Institute of Public Health
  • OGATA Akio
    Department of Environmental Health and Toxicology, Tokyo Metropolitan Institute of Public Health
  • KAMIMURA Hisashi
    Department of Environmental Health and Toxicology, Tokyo Metropolitan Institute of Public Health

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Other Title
  • 遺伝子組換え大豆のＦ３４４ラットによる５２週間摂取試験
  • イデンシ クミカエ ダイズ ノ F344 ラット ニ ヨル 52シュウカン セッシュ シケン

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A chronic feeding study to evaluate the safety of the genetically modified glyphosate-tolerant soybeans (GM soybeans) was conducted using rats. F344 DuCrj rats were fed diet containing GM soybeans or Non-GM soybeans at the concentration of 30% in basal diet. Non-GM soybeans were closely related strain of GM soybeans. These two diets were adjusted to an identical nutrient level. In this study, the influence of GM soybeans on rats was compared with that of the Non-GM soybeans, and furthermore, to assess the effect of soybeans themselves, the groups of rats fed GM and Non-GM soybeans were compared with a group fed commercial diet (CE-2). General conditions were observed daily and body weight and food consumption were recorded. At the intermediate examination (26 weeks), and at the termination (52 weeks), animals were subjected to hematology, serum biochemistry, and pathological examination. There were several differences in animal growth, food intake, serum biochemical parameters and histological findings between the rats fed the GM and /or Non-GM soybeans and the rats fed CE-2. However, body weight and food intake were similar for the rats fed the GM and Non-GM soybeans. Gross necropsy findings, hematological and serum biochemical parameters, organ weights, and pathological findings showed no meaningful difference between rats fed the GM and Non-GM soybeans. These results indicate that long-term intake of GM soybeans at the level of 30% in diet has no apparent adverse effect in rats.

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