Screening Assay of Residual Antibiotics in Livestock Samples by LC-MS/MS
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- NAKAJIMA Takayuki
- Tokyo Metropolitan Institute of Public Health
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- SASAMOTO Takeo
- Tokyo Metropolitan Institute of Public Health
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- HAYASHI Hiroshi
- Tokyo Metropolitan Institute of Public Health
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- KANDA Maki
- Tokyo Metropolitan Institute of Public Health
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- TAKEBA Kazue
- Tokyo Metropolitan Institute of Public Health
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- KANAI Setsuko
- Tokyo Metropolitan Institute of Public Health
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- KUSANO Tomoko
- Tokyo Metropolitan Institute of Public Health
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- MATSUSHIMA Yoko
- Tokyo Metropolitan Institute of Public Health
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- TAKANO Ichiro
- Tokyo Metropolitan Institute of Public Health
Bibliographic Information
- Other Title
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- LC-MS/MSによる畜産食品中抗生物質のスクリーニング試験法
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Abstract
A LC-MS/MS screening assay of multi-class antibiotics was developed for 19 residual antibiotics in livestock samples. Sample preparation employed the QuEChERS (Quick, Easy, Cheap, Effective, Rugged and Safe) approach using 0.5% formic acid in acetonitrile–methanol (8 : 2), with salting-out using magnesium sulfate, trisodium citrate and sodium chloride. Recovery values from 5 different livestock samples ranged from 45.5 to 121.6%, and the RSDs were under 18% at two concentration levels. The limit of quantification values of 19 analytes were under 10 μg/kg in all livestock samples, and the procedure can detect almost all analytes under the MRL. Screening capability was confirmed by employing spiked samples. This new screening assay for residual antibiotics in livestock samples is expected to be useful for routine laboratory tests.
Journal
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- Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi)
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Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi) 53 (2), 91-97, 2012-04-25
Japanese Society for Food Hygiene and Safety
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Details 詳細情報について
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- CRID
- 1390001204225790336
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- NII Article ID
- 130002109179
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- NII Book ID
- AN00117741
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- COI
- 1:CAS:528:DC%2BC38XhtVSntL3N
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- ISSN
- 18821006
- 00156426
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- NDL BIB ID
- 023761486
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- PubMed
- 22688024
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- Text Lang
- en
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- Data Source
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- JaLC
- IRDB
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed