Gas Chromatography of Dulcin (II)

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Other Title
  • ズルチンのガスクロマトグラフィー (第2報)
  • ユウドウタイ ニ ヨル テイリョウホウ ノ ケントウ ニ ツイテ
  • Determination of Dulcin by Its Derivatives
  • 誘導体による定量法の検討について

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In this report, the determination of dulcin was carried out by after conversion to its derivatives. The results were as follows:<BR>When dulcin was reacted with acetic anhydride-pyridine mixture (1: 4) in boiling water bath for 20 minutes, the product showed a single peak of acetophenetidine gas chromatographically, having a linear relation between the peak heights and amounts of dulcin. In case trifluoroacetic anhydride was added and reacted with dulcin in dichloromethane at room temperature for 5 minutes, trifluoroaceto-p-phenetidine was produced. For the determination of dulcin, the linearity and precision of this method were less than those of the acetylation method, though the procedure was simple and rapid. Dulcin reacted with bis- (trimethyl silyl) -acetamide, and on the gas chromatogram, obtained by using non-polar column, the reaction mixture showed two major peaks which were presumed to be those of mono-and di-trimethyl silyl derivatives of dulcin.

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