Determination of Carbendazim, Thiophanate, Thiophanate-methyl and Benomyl Residues in Agricultural Products by Liquid Chromatography-Tandem Mass Spectrometry
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- NAKAMURA Munetomo
- Japan Food Research Laboratories
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- FURUMI Yasuko
- Japan Food Research Laboratories
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- WATANABE Fumiko
- Japan Food Research Laboratories
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- MIZUKOSHI Kazushi
- Japan Food Research Laboratories
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- TANIGUCHI Makoto
- Mimasaka University
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- NEMOTO Satoru
- National Institute of Health Sciences
Bibliographic Information
- Other Title
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- LC-MS/MSによる農作物中のカルベンダジム,チオファネート,チオファネートメチルおよびベノミルの残留分析
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Abstract
A simple and reliable liquid chromatographic-tandem mass spectrometric (LC-MS/MS) method was developed for carbendazim (MBC), thiophanate (TE), thiophanate-methyl (TM) and benomyl (BM) in agricultural products. These compounds were extracted from agricultural products with methanol after addition of sodium L-ascorbate. BM was hydrolyzed to MBC during the extraction with methanol. TE and TM were cyclized to ethyl 2-benzimidazole carbamate (EBC) and MBC by refluxing at 120°C for 30 min with copper acetate in 50% acetic acid. MBC and EBC were cleaned up by an n-hexane wash and extraction with ethyl acetate and determined by LC-MS/MS. The mean recoveries from 10 agricultural products were in the range of 75.8-100.0%, and the relative standard deviations of 5 experiments were in the range of 1.5-9.2% at concentrations equal to the maximum residue limits (MRLs). The calibration curves were made by using commercial MBC and EBC as reference analytical standards without refluxing. The quantification limits were 0.01 mg/kg (as MBC), which is the uniform limit in the positive list system for agricultural chemical residues in foods in Japan.
Journal
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- Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi)
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Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi) 52 (3), 148-155, 2011
Japanese Society for Food Hygiene and Safety
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Details 詳細情報について
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- CRID
- 1390001204226023680
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- NII Article ID
- 130000909920
- 40018907887
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- NII Book ID
- AN00117741
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- ISSN
- 18821006
- 00156426
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- NDL BIB ID
- 11166869
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed