Pharmacological Studies on Alkylbenzene Sulfonate (2)

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  • アルキルベンゼンスルホン酸ナトリウム (ABS) の薬理学的研究 (2)
  • アルキルベンゼンスルホンサン ナトリウム ABS ノ ヤクリガクテキ ケンキュウ 2 ニンシン ラット マウス エ ノ ABS トウヨ ノ タイシ ナラビニ シンセイシ ニ オヨボス エイキョウ
  • Effects of Oral Administration during Pregnancy on Fetus and New Born in Mice and Rats
  • 妊娠ラット・マウスへのABS投与の胎仔ならびに新生仔に及ぼす影響

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Administration of ABS to rats during pregnancy caused diarrhea and suppression of body weight gain in groups given 1.0% and 2.0% diet. No remarkable effect was observed in groups given 0.5%, 0.1% and 0.025% diet. Although pregnancy was maintained even in 2.0% group the increase of fetal death and the decrease in fetal development was observed in the group. No macroscopic malformation, assumed to be caused by the administration of ABS, was observed. No deleterious effect on delivery and lactation as well as on development of new-born until 5 weeks after parturition was observed.<BR>Oral administration of aqueous ABS to pregnant mice between 7 and 13 day of pregnancy caused slight effect on maternal weight gain, but no effect was observed in fetus from dams given 24mg/kg ABS. Administration of 240mg/kg caused increase of fetal development suppression and death on 18th day of pregnancy. Occurrence of congenital malformation, assumed to be originated from ABS administration, was not observed.

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