Determination of 4-Hydroxycoumarin Rodenticides in Animal Products, Fishery Products, and Honey by Liquid Chromatography-Tandem Mass Spectrometry
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- SAITO Shizuka
- National Institute of Health Sciences
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- SAKAI Takatoshi
- National Institute of Health Sciences
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- NEMOTO Satoru
- National Institute of Health Sciences
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- MATSUDA Rieko
- National Institute of Health Sciences
Bibliographic Information
- Other Title
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- LC-MS/MSによる畜水産物およびはちみつ中の4-ヒドロキシクマリン系殺鼠剤分析法
- LC MS MS ニ ヨル チクスイサンブツ オヨビ ハチミツ チュウ ノ 4 ヒドロキシクマリンケイ サッソザイ ブンセキホウ
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Abstract
A sensitive and selective method for the determination of 4-hydroxycoumarin-type rodenticides (warfarin, coumatetralyl, bromadiolone, and brodifacoum) in animal products, fishery products, and honey was developed. 4-Hydroxycoumarin rodenticides were extracted with acidified acetone, and the crude extract was purified by liquid-liquid partitioning followed by PSA column cleanup. Gradient liquid chromatographic separation was performed by using an Inertsil ODS-4 column, with methanol and water containing ammonium acetate as the mobile phase. Detection was carried out on a tandem mass spectrometer with electrospray ionization in the negative mode. Average recoveries from bovine muscle, bovine liver, bovine fat, swine muscle, salmon, eel, freshwater clam, egg, milk, and honey spiked at 0.0005-0.001 mg/kg were in the range of 79-108%, and the relative standard deviations were 2-8%. The limits of quantitations of the developed method were 0.0005 mg/kg for brodifacoum, 0.001 mg/kg for warfarin, coumatetralyl, and bromadiolone.
Journal
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- Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi)
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Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi) 52 (4), 244-250, 2011
Japanese Society for Food Hygiene and Safety
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Details 詳細情報について
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- CRID
- 1390001204227208064
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- NII Article ID
- 130001077721
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- NII Book ID
- AN00117741
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- ISSN
- 18821006
- 00156426
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- NDL BIB ID
- 11227785
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- PubMed
- 21873815
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- Text Lang
- ja
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- Data Source
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- JaLC
- IRDB
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed