海藻中に含まれる有機ヒ素化合物・アルセノ糖の培養細胞を用いた毒性学的研究

DOI 日本農学文献記事索引 Web Site 被引用文献7件 参考文献39件

書誌事項

タイトル別名
  • Toxicological Study of Organic Arsenic Compound in Marine Algae using Mammalian Cell Culture Technique
  • カイソウチュウ ニ フクマレル ユウキ ヒソ カゴウブツ アルセノ トウ ノ

この論文をさがす

抄録

Marine organisms frequently contain arsenic in higher concentrations than terrestrial organisms. The water-soluble arsenoriboses are the major organic arsenic compounds in marine algae. We synthesized an arsenosugar, 1-(2′, 3′-dihydroxypropyl)-5-deoxyribosyldime-thylarsine oxide, and examined this compound for cytotoxicity (50%-inhibitory dose; ID50) and for the ability to induce chromosomal aberration and sister chromatid exchanges (SCE). The arsenosugar inhibited the growth of BALB/c 3T3 cells at a concentration of 2mg arsenosugar/ml in the cytotoxicity test. The cytotoxicity of this compound was 1/2800th of that of sodium arsenite and 1/300th of that of sodium arsenate. The aberrations caused by the arsenosugar at a concentration of 5mg/ml consisted mainly of chromatid gaps and chromatid breaks. No SCE was observed at concentrations of 1 to 10mg/ml. These results suggest that the arsenosugar present in marine algae is much less toxic than inorganic arsenic compounds.

収録刊行物

  • 食品衛生学雑誌

    食品衛生学雑誌 37 (3), 135-141_1, 1996

    公益社団法人 日本食品衛生学会

被引用文献 (7)*注記

もっと見る

参考文献 (39)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ