Toxicological Study of Organic Arsenic Compound in Marine Algae using Mammalian Cell Culture Technique
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- KAISE Toshikazu
- Tokyo University of Pharmacy and Life Science
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- OYA-OHTA Yukiko
- Kanagawa Prefectural College of Nursing and Medical Technology
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- OCHI Takafumi
- Teikyo University
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- OKUBO Tohru
- National Federation of Fisheries Cooperative Associations
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- HANAOKA Ken'ichi
- Shimonoseki University of Fisheries
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- IRGOLIC Kurt J.
- Karl Franzens University Graz
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- SAKURAI Teruaki
- Tokyo University of Pharmacy and Life Science
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- MATSUBARA Chiyo
- Tokyo University of Pharmacy and Life Science
Bibliographic Information
- Other Title
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- 海藻中に含まれる有機ヒ素化合物・アルセノ糖の培養細胞を用いた毒性学的研究
- カイソウチュウ ニ フクマレル ユウキ ヒソ カゴウブツ アルセノ トウ ノ
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Description
Marine organisms frequently contain arsenic in higher concentrations than terrestrial organisms. The water-soluble arsenoriboses are the major organic arsenic compounds in marine algae. We synthesized an arsenosugar, 1-(2′, 3′-dihydroxypropyl)-5-deoxyribosyldime-thylarsine oxide, and examined this compound for cytotoxicity (50%-inhibitory dose; ID50) and for the ability to induce chromosomal aberration and sister chromatid exchanges (SCE). The arsenosugar inhibited the growth of BALB/c 3T3 cells at a concentration of 2mg arsenosugar/ml in the cytotoxicity test. The cytotoxicity of this compound was 1/2800th of that of sodium arsenite and 1/300th of that of sodium arsenate. The aberrations caused by the arsenosugar at a concentration of 5mg/ml consisted mainly of chromatid gaps and chromatid breaks. No SCE was observed at concentrations of 1 to 10mg/ml. These results suggest that the arsenosugar present in marine algae is much less toxic than inorganic arsenic compounds.
Journal
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- Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi)
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Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi) 37 (3), 135-141_1, 1996
Japanese Society for Food Hygiene and Safety
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Keywords
Details 詳細情報について
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- CRID
- 1390001204227289216
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- NII Article ID
- 10009286242
- 10004821249
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- NII Book ID
- AN00117741
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- ISSN
- 18821006
- 00156426
- http://id.crossref.org/issn/00156426
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- NDL BIB ID
- 3977463
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- Data Source
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- JaLC
- IRDB
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed