Pharmacological Studies on Japanese “Sake” and Some Other Alcoholic Beverages

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  • AKABANE Jiro
    Department of Pharmacology, Faculty of Medicine, Shinshu University
  • NAKANISHI Suehiro
    Department of Pharmacology, Faculty of Medicine, Shinshu University
  • KOHEI Hiroshi
    Department of Pharmacology, Faculty of Medicine, Shinshu University

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Other Title
  • 清酒ほか諸種の酒類の薬理作用に関する実験的研究

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Abstract

Toxicities of alcoholic beverages (Japanese “sake”, synthetic “sake”, “shochu”-a distilled alcoholic drink, “dakushu”-an unrefined “sake”, whisky and brandy) were pharmacologically studied using experimental animals. Lethal dose (LD50) in mouse, effects on respiration and blood pressure of dogs and rabbits, effects on the movement of the isolated heart of toads, electrocardiogram of rabbits and effects on the movement of the excised uterus and small intestine of rats and rabbits were studied.<BR>The pharmacological effects were much more obvious either in the brewed or distilled alcoholic drinks whose impurities were found to be much. The intensive effects were observed in the brewed Japanese “sake” and, in particular, the maximum toxicities were observed in the unrefined “dakushu”.<BR>The effects of the synthetic “sake” was in the same order as those of the alcohol-Ringer solution whose content of alcohol was the same as that of the synthetic “sake”.<BR>The toxic effects were not observed in the volatile fraction obtained by the distillation of the Japanese “sake”. On the contrary, the toxic effects of the congeners of the Japanese “sake” in the fraction of unvolatile extract were observed to be most intensive.

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