Experimental Studies on Toxicity of Tropolone (II)

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  • トロポロンの毒性に関する実験的研究 (第2報)
  • Effects of Subacute Administration of Tropolone Sodium
  • トロポロンナトリウムの亜急性毒性実験

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Subacute administration of Tropolone-Na was performed on dd-strain mice and Wistarstrain rats, and the following results were obtained.<BR>1) The maximal tolerance dose to a mouse is presumed to be 48mg/kg or over.<BR>2) The minimal toxic dose to a mouse is 26-48mg/kg.<BR>3) The histological changes are most significant in the liver and kidneys in mice.<BR>4) The maximal tolerance dose to a rat is presumed to be 36mg/kg or over.<BR>5) The minimal toxic dose to a rat is 18-36mg/kg.<BR>6) The histological changes, though mild, are seen most frequently in the liver and kidneys in rats.<BR>7) When Tropolone-Na is used to maintain freshness of fishery products, it is regarded to be perfectly safe to men. It is, however, not always safe when for boiled fishpaste.

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