Mutations of the APC(Adenomatous Polyposis Coli) Gene in FAP(Familial Polyposis Coli) Patients and in Sporadic Colorectal Tumors.
-
- NAKAMURA YUSUKE
- Department of Biochemistry, Cancer Institute
-
- NISHISHO ISAMU
- Department of Biochemistry, Cancer Institute
-
- KINZLER KENNETH W.
- Oncoloty Center, The Johns Hopkins University School of Medicine
-
- VOGELSTEIN BERT
- Oncoloty Center, The Johns Hopkins University School of Medicine
-
- MIYOSHI YASUO
- Department of Biochemistry, Cancer Institute
-
- MIKI YOSHIO
- Department of Biochemistry, Cancer Institute
-
- ANDO HIROSHI
- Department of Biochemistry, Cancer Institute
-
- HORII AKIRA
- Department of Biochemistry, Cancer Institute
説明
NAKAMURA, Y., NISHINO, I., KINZLER, K.W., VOGELSTEIN, B., MIYOSHI, Y., MIKI, Y., ANDO, H. and HORII, A. Mutations of the APC (Adenomatous Polyposis Coli) Gene in PAP (Familial Polyposis Coli) Patients and in Sporadic Colorectal Tumors. Tohoku J. Exp. Med., 1992, 168 (2), 141-147 - We have isolated several genes on chromosome 5q21 region tightly linked to hereditary familial polyposis coli (FAP) and Gardner's syndrome (GS). Two of these genes (MCC and APC) were found to be somatically altered by point mutation, deletion or insertion in tumors of sporadic colorectal cancer patients. One (APO) of them was also found mutations in the germ line of both APC and GS patients. The identification of these genes has significant implications for understanding the pathogenesis of colorectal neoplasia and for the diagnosis and counseling of individuals with inherited predispositions to colorectal cancer. - adenomatous polyposis coli (APC) gene; chromosome 5q21; familial polyposis coli (FAP); Gardner's syndrome (GS); mutation
収録刊行物
-
- The Tohoku Journal of Experimental Medicine
-
The Tohoku Journal of Experimental Medicine 168 (2), 141-147, 1992
東北ジャーナル刊行会
