Poly-adenosine diphosphate ribose autoantibody in systemic lupus erythematosus and other related autoimmune diseases.
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- MURATA KATSUMI
- Department of Medicine and Physical Therapy, University of Tokyo School of Medicine
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- TAKAFUJI SHIGERU
- Department of Medicine and Physical Therapy, University of Tokyo School of Medicine
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- MIZOGUCHI TOKUKO
- Department of Medicine and Physical Therapy, University of Tokyo School of Medicine
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- NAGASHIMA KOJI
- Tokyo Institute of Seikagaku Kogyo
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- OKAZAKI HIDEO
- Tokyo Institute of Seikagaku Kogyo
Bibliographic Information
- Other Title
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- Poly Adenosine Diphosphate Ribose Autoa
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Abstract
MURATA, K., TAKAFUJI, S., MIZOGUCHI, T., NAGASHIMA, K. and OKAZAKI, H. Poly-Adenosine Diphosphate Ribose Autoantibody in Systemic Lupus Erythematosus and Other Related Autoimmune Diseases. Tohoku J. exp. Med., 1983, 140 (4), 369-379 - The binding activities of poly-adenosine diphosphate-ribose (ADPR) and ds-DNA were measured in the sera of patients with systemic lupus erythematosus (SLE) and other collagen diseases in comparison with normal subjects. High polyADPR binding activity was detected in the SLE sera. The polyADPR binding assay was as sensitive as the DNA binding assay for diagnosing SLE. In SLE sera, the increased polyADPR binding activity was correlated with that of ds-DNA and negatively with the complement (CH50) titer. With improvement of clinical symptoms of SLE, the binding activity of polyADPR decreased in parallel to the binding activity of ds-DNA and oppositive to the CH50 titer. The polyADPR binding activity was occasionally high in other collagen diseases. Effects of steroid treatment of SLE on the binding activities of polyADPR and ds-DNA, and CH50 titer were examined over half a year, indicating that both binding activities are reliable parameters for judgement of the clinical course.
Journal
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- The Tohoku Journal of Experimental Medicine
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The Tohoku Journal of Experimental Medicine 140 (4), 369-379, 1983
Tohoku University Medical Press
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Details 詳細情報について
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- CRID
- 1390001204238939904
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- NII Article ID
- 130003493165
- 40005307102
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- NII Book ID
- AA00863920
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- COI
- 1:CAS:528:DyaL3sXlt1Smt7g%3D
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- ISSN
- 13493329
- 00408727
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- NDL BIB ID
- 2637125
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- PubMed
- 6636136
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed