The effect of RES blockade on red blood cell survival.

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  • UCHIDA TATSUMI
    The First Department of Internal Medicine, Fukushima Medical College
  • MATSUDA SHIN
    The First Department of Internal Medicine, Fukushima Medical College
  • TANAKA TETSUGORO
    The First Department of Internal Medicine, Fukushima Medical College
  • SATO TADASHI
    The First Department of Internal Medicine, Fukushima Medical College
  • YUI TOKUO
    The First Department of Internal Medicine, Fukushima Medical College
  • KOKUBUN REIKO
    The First Department of Internal Medicine, Fukushima Medical College
  • KUMANO MASASHI
    The First Department of Internal Medicine, Fukushima Medical College
  • KARIYONE SHIGEO
    The First Department of Internal Medicine, Fukushima Medical College

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  • Effect of RES Blockade on Red Blood Cel

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UCHIDA, T., MATSUDA, S., TANAKA, T., SATO, T., YUI, T., KOKUBUN, R., KUMANO, M. and KARIYONE, S. The Effect of RES Blockade on Red Blood Cell Survival. Tohoku J. exp. Med., 1981, 135 (3), 247-253-The effect of RES blockade on the survival of heat-damaged and antibody coated red blood cells was evaluated in C3H mice. RES function of C3H mice was determined by the survival of 59Fe-labeled, heat-damaged red blood cells at 49°C for 30min. When animals were treated with an intravenous injection of non-labeled, heat-damaged red blood cells for the blockade of RES, red blood cell destruction was depressed in non-splenectomized and splenectomized mice. In the survival or organ distribution of 59Fe-labeled, antibody-coated red blood cells, no difference was noted between animals with and without blockade. These findings suggest that heat-damaged red blood cells were destructed predominantly in the splenic RES and antibody coated cells were not broken down only by the splenic RES.

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