Effect of Manganese on the AV Node of Dog <i>in situ</i>

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MnCl2 induced negative dromotropic effect on the AV node of dogs in situ. At a dose level above 10mg, a transient AV block was observed. The injection of 1-3mg of MnCl2 suppressed the acceleration of AV nodal rhythm, which was induced by administration of 1 μg of norepinephrine.

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