5-Hydroxytryptamine(serotonin)and 5-hydroxytryptopham in mast cells of human mastocytosis

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  • 5-Hydroxytryptamine (Serotonin) and 5-Hydroxytryptophan in Mast Cells of Human Mastocytosis

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With use of the formaldehyde condensation method of Flack and Hillarp, skin specimens taken from one patient with solitary mastocytosis and four patients with urticaria pigmentosa were examined under a fluorescence microscope. In the case of solitary mastocytosis, some of mast cells in the dermis showed intense yellow fluorescence, which was no doubt due to the presence of serotonin or its immediate precursor, 5-hydroxytryptophan. In four cases of urticaria pigmentosa, no yellow fluorescence could be detected on the mast cells infiltrated around the vessels. However, there were a few mast cells which showed yellow fluorescence, in the dermis of a patient with urticaria pigmentosa. From a biochemical point of view, human mast cells, too, seem to consist of two distinctly different types of cells: monoamine-forming and non-amine-forming mast cells.

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