The Role of Transfer Agent in Immunity

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Immune ribonucleic acid (RNA) preparations were obtained from the culture filtrate of peritoneal macrophages derived from immunized animals. These agents were also extractable from the peritoneal exudates or spleen cells of immunized animals and were capable of inducing the proliferation of antibody-forming cells, when injected into either conventional or germ-free animals. When injected, these agents were able to induce ‘memory’ cells capable of responding to a secondary stimulus with an antigen and producing a high titer of serum antibody. However, secondary responses were not induced by injections of immune RNA preparations into animals primed with either corresponding antigen or immune RNA preparation. It was also demonstrated that the ability of immune RNA preparations to induce either antibody formation or memory cells was inactivated by treatment with RNase but not with proteinases such as trypsin and pronase. These results indicated that previous stimulation by an antigen was not needed for the induction of antibody formation by immune RNA and that this agent did not contain antigens or fragments thereof.

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