Plasma Glucagon Response to Blood Glucose Fall, Gastrointestinal Hormones and Arginine in Man
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- OHNEDA AKIRA
- The Third Medical Department, Tohoku University School of Medicine
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- SATO MUNEHIKO
- The Third Medical Department, Tohoku University School of Medicine
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- MATSUDA KIYOSHI
- The Third Medical Department, Tohoku University School of Medicine
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- YANBE AKIRA
- The Third Medical Department, Tohoku University School of Medicine
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- MARUHAMA YOSHISUKE
- The Third Medical Department, Tohoku University School of Medicine
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- YAMAGATA SHOICHI
- The Third Medical Department, Tohoku University School of Medicine
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The response of plasma glucagon to several stimuli was studied and compared in normal and diabetic subjects. Plasma glucagon was measured by the radioimmunoassay using an anti-glucagon serum, which is relatively specific for pancreatic glucagon. Insulin-induced hypoglycemia caused a marked elevation of plasma glucagon in normal subjects but minimal in diabetic patients. A rapid fall of blood glucose, cataglycemia, induced by the discontinuation of glucose infusion did not show any changes in the level of plasma glucagon. The response of plasma glucagon was not observed after the injection of tetrapeptide of gastrin or secretin, although these hormones induced an increase in the level of plasma insulin. Pancreozymin did not induce any changes in plasma insulin or glucagon in a dosis of one clinical unit per kg of body weight. The infusion of 30g of L-arginine stimulated the secretion of pancreatic glucagon and the plasma level of glucagon was moderately elevated in both normal and diabetic subjects. These results suggest that L-arginine infusion is recommended as a tool for the alpha-cell function test of the pancreas in man.
収録刊行物
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- The Tohoku Journal of Experimental Medicine
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The Tohoku Journal of Experimental Medicine 107 (3), 241-251, 1972
東北ジャーナル刊行会
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詳細情報 詳細情報について
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- CRID
- 1390001204240737536
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- NII論文ID
- 130003407493
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- NII書誌ID
- AA00863920
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- COI
- 1:CAS:528:DyaE38Xls1Sntrs%3D
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- ISSN
- 13493329
- 00408727
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- NDL書誌ID
- 7672298
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- PubMed
- 4639665
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可