Effect of Furylfuramide on Reproduction and Malformation

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  • MIYAJI TORU
    Department of Pathology, Osaka University Medical School

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As food additives are prone to be taken every day, it was considered important to test their effect on reproduction and their possible teratogenecity. Mice and rats were fed 0.0125% Furylfuramide diet continuously for four generations, and per cent of conception, birth rate, number of litter per female, rate of weaning and body weight at the time of weaning were examined. There was no difference between animals fed Furylfuramide and control diet.<br> Teratogenicity of Furylfuramide was studied on mice and compared with that of Nitrofurazone and control diet. Furylfuramide did not have any teratogenic effect on fetuses and no malformation was noted among fetuses obtained by Cesarean section. Fertility of male mice was not impaired by Furylfuramide feeding in contrast to Nitrofurazone, which reduced fertility of males. The fetuses were smaller in size compared with the Furylfuramide group and controls.

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