Free Amino Acid Pattern in the Brain from Rats with Hyperaminoacidemia

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  • TADA KEIYA
    Department of Pediatrics, Tohoku University School of Medicine
  • TAKADA GORO
    Department of Pediatrics, Tohoku University School of Medicine
  • ARAKAWA TSUNEO
    Department of Pediatrics, Tohoku University School of Medicine

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Hyperaminoacidemia was induced in 17-day-old rats by intra-peritoneal injection of a single amino acid and the free amino acid pattern in the brain was analyzed at 1 hour after the injection. A significant alternation of the free amino acid pattern in the brain was observed by the loading of phenylalanine, histidine, valine, methionine or glycine, respectively. These findings suggest that the inhibition of amino acid transport by excess of a single amino acid may result in decrease of essential amino acids and in reduced rate of brain protein synthesis.

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