The effects of glibenclamide on lipid content of the aorta and plasma lipoprotein in normal rabbits.

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  • OHIRA SEIICHI
    Department of Internal Medicine, Hirosaki University School of Medicine
  • ONUMA TOMIO
    Department of Internal Medicine, Hirosaki University School of Medicine
  • TAKEBE KAZUO
    Department of Internal Medicine, Hirosaki University School of Medicine

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タイトル別名
  • Effects of Glibenclamide on Lipid Conte

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The study was performed on 12 male rabbits, which were divided into two groups; one group of 7 rabbits fed on commercial rabbit pellet mixed with 2 mg of glibenclamide per kg of the food (G-group), and the other of 5 rabbits fed on rabbit pellet only without mixing glibenclamide as the control group (C-group). The food intake was limited to 200 g daily. Three months later, the blood was collected from these rabbits in fasting state for determination of blood sugar and IRI, and lipoprotein analysis. Then, the aorta was taken out for determination of cholesterol and cholesterol ester. There was no significant difference between both groups in terms of weight gain, blood sugar and IRI, while cholesterol content in the aorta of G-group (2.68±0.12 mg/g wet weight) was significantly higher (p<0.05) than that of C-group (2.28±0.12 mg/g wet weight). HDL-cholesterol level was similar in both groups, while LDL-cholesterol of G-group (10.8±2.3 mg/100 ml) was higher than that of C-group (7.3±1.5 mg/100 ml). These results suggest that glibenclamide may have atherogenicity in normal rabbits probably because of an increment of LDL-cholesterol.

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