Effects of flavine adenine dinucleotide on the platelet aggregation induced by collagen or ADP.
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- SHIMADA KENICHI
- Department of Pediatrics, Akita University School of Medicine
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- ISHIGAKI WAKAKO
- Department of Pediatrics, Akita University School of Medicine
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- HASHIMOTO TEIJI
- Department of Pediatrics, Akita University School of Medicine
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- YATABE MICHIO
- Department of Pediatrics, Akita University School of Medicine
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- SASAKI GOICHI
- Department of Pediatrics, Akita University School of Medicine
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- HIGASHI OTOTAKA
- Department of Pediatrics, Akita University School of Medicine
Bibliographic Information
- Other Title
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- Effects of Flavine Adenine Dinucleotide
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Description
It was revealed in the present study that flavine adenine dinucleotide (FAD) could inhibit both collagen- and ADP-induced aggregation of human platelets in vitro at the final concentrations of micromolar level. Also flavine mononucleotide and riboflavin showed a moderate degree of inhibition on the ADP-induced platelet aggregation. FAD may enhance further the inhibition of platelet aggregation by aspirin, suggesting different mechanism. The possible mechanism under-lying the inhibition of platelet aggregation in vitro by FAD and related sub-stances was discussed. Also, a preliminary study has suggested that the inhibitory effect of FAD on the platelet aggregation was observable not only in vitro, but also in vivo. The intravenous administration of a relatively high dose of FAD to a few patients with various diseases was followed by a slight and transient decrease of the collagen-induced platelet aggregation.
Journal
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- The Tohoku Journal of Experimental Medicine
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The Tohoku Journal of Experimental Medicine 130 (3), 219-226, 1980
Tohoku University Medical Press
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Details 詳細情報について
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- CRID
- 1390001204240941568
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- NII Article ID
- 130003492686
- 40005306590
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- NII Book ID
- AA00863920
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- COI
- 1:CAS:528:DyaL3cXksVamu78%3D
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- ISSN
- 13493329
- 00408727
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- NDL BIB ID
- 2210997
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed