Enhancement of the Cancer Chemotherapeutic Effect by Anticancer Agents in the Form of Fat Emulsion
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- TAKAHASHI TOSHIO
- Department of Surgery, Akita University School of Medicine
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- KONO KENICHI
- Department of Surgery, Akita University School of Medicine
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- YAMAGUCHI TOSHIHARU
- Department of Surgery, Akita University School of Medicine
Bibliographic Information
- Other Title
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- Enhancement of the Cancer Chemotherapeu
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Abstract
Utilizing the lipid-absorbing ability of lymphatic capillaries, anticancer agents were given in the form of fat emulsion in order to deliver them to regional lymph nodes. The emulsion, in which the drug solution is contained as the innermost phase, yielded high drug concentration in the lymphatic system. Intratumoral injection of emulsified anticancer agent resulted in significantly prolonged retension of the drug within the tumor tissue. Therapeutic experiments of the emulsion also disclosed remarkable tumor reduc-tion and cure rate as compared with aqueous solution of drugs. Oral admini-stration of emulsified 5-Fluorouracil (5-FU) was also attempted for stomach cancer. With 5-FU, the maximum concentration of drug in thoracic lymph and stomach was greater when administered as an emulsion than as an aqueous solution, and a high concentration persisted longer. As a clinical trial of the emulsion method, eight patients with inoperable malignant growth were injected locally with emulsi-fied anticancer agents and 121 patients were given 5-FU emulsion orally. From the clinical and histological findings, it was thought that the emulsion enhanced the chemotherapeutic effect of the anticancer agent on lymph node metastasis.
Journal
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- The Tohoku Journal of Experimental Medicine
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The Tohoku Journal of Experimental Medicine 123 (3), 235-246, 1977
Tohoku University Medical Press
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Details 詳細情報について
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- CRID
- 1390001204241344256
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- NII Article ID
- 130003407650
- 40005306012
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- NII Book ID
- AA00863920
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- COI
- 1:CAS:528:DyaE1cXpsVOltw%3D%3D
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- ISSN
- 13493329
- 00408727
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- NDL BIB ID
- 1914722
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- PubMed
- 74867
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed