Abnormalities of Iodine and Protein in the Thyroid of Patients with Hashimoto′s Thyroiditis

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  • YAMAMOTO MAKIKO
    The Second Department of Internal Medicine, Tohoku University School of Medicine
  • SAITO SHINTARO
    The Second Department of Internal Medicine, Tohoku University School of Medicine
  • SAKURADA TOSHIRO
    The Second Department of Internal Medicine, Tohoku University School of Medicine
  • KAISE KAZURO
    The Second Department of Internal Medicine, Tohoku University School of Medicine
  • KAISE NOBUKO
    The Second Department of Internal Medicine, Tohoku University School of Medicine
  • YOSHIDA KATSUMI
    The Second Department of Internal Medicine, Tohoku University School of Medicine
  • KITAOKA HIROFUMI
    The Second Department of Internal Medicine, Tohoku University School of Medicine
  • FUKAZAWA HIROSHI
    The Second Department of Internal Medicine, Tohoku University School of Medicine
  • YOSHINAGA KAORU
    The Second Department of Internal Medicine, Tohoku University School of Medicine

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  • Abnormalities of iodine and protein in the thyroid of patients with Hashimoto's thyroiditis.
  • Abnormalities of Iodine and Protein in

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YAMAMOTO, M., SAITO, S., SAKURADA, T., KAISE, K., KAISE, N., YOSHID. K., KITAOKA, H., FUKAZAWA, H. and YOSHINAGA, K. Abnormalities of Iodine and Protein in the Thyroid of Patients with Hashimoto's Thyroiditis.Tohoku J. exp. Med., 1981, 135 (3), 323-330-Iodine content, protein content and percentage of thyroglobulin to total protein in the thyroid glands were studied in two groups of 10 patients with Hashimoto's thyroiditis (5 euthyroid and 5 hypothyroid patients) and in 6 normal subject. Iodine content was significantly decreased in both hypothyroid (24+29μg/g wet weight of thyroid tissue, mean±S.D., p<0.01) and euthyroid (96+52, p<0.01) groups of Hashimoto's thyroiditis compared with those in controls (779+37). The value of hypothyroid group was significantly smaller than that of euthyroid group (p<0.05). A significant negative correlation was obtained between thyroidal iodine content and serum TSH (r=-0.68, y=-0.41x+55.6, p<0.05). Thyroidal protein and percentage of thyroglobulin to total thyroidal protein were also decreased in Hashimoto's thyroiditis compared with controls, while there was no difference between euthyroid and hypothyroid groups in these values. The percentage of thyroglobulin-bound 131I obtained by in vitro iodination of thyroglobulin in Hashimoto's thyroiditis appeared to be decreased in 2 cases of hypothyroid group. Some immunological reaction occurring in Hashimoto's thyroiditis may change the structure of thyroglobulin and in turn the normal iodination of thyroglobulin may be disturbed.-Hashimoto's thyroiditis; thyroidal iodine; thyroidal protein; thyroglobulin; in vitro iodination

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