Urinary Estriol as an Index of Placental Function

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  • Aoba Hisao
    Department of Obstetrics and Gynecology (Prof. K. Kushima), Tohoku University School of Medicine

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To assess the placental function, urinary excretion of estriol was estimated by the method developed by Kanbegawa. In normal pregnancy the mean urinary estriol always showed high values throughout the pregnancy, whereas in complicated pregnancy such as toxemia, retarded fetal growth and fetal death, it showed low values. Correlation between urinary value of estriol and feto-placental weight ratio was significant. The value of urinary estriol less than 10mg/day at term would imply placental dysfunction. Estimation of urinary estriol after administration of Diamox is much useful in the evaluation of the prognosis.

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