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- Fukushima Matsuro
- The Surgical Clinic, Hirosaki University School of Medicine
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- Ishikawa Yoshinobu
- The Surgical Clinic, Hirosaki University School of Medicine
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- Horimai Takahisa
- The Surgical Clinic, Hirosaki University School of Medicine
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- Adachi Minoru
- The Surgical Clinic, Hirosaki University School of Medicine
Search this article
Abstract
For the purpose of evaluating the clinical value of ‘in vitro’ sensitivity test of cancer cells to anticancer drugs and the clinical significance of uric acid concentration in the serum and urine after cancer chemotherapy, some experiments were carried out on the DiPaolo's cell agar plate method, and the uric acid level in the serum and urine after the administration of anticancer drugs were examined.<br> In cases of experimental ascites and solid tumor, DiPaolo's method gave nearly satisfactory results, but in the tests with human cancer cells the method was proved to be available only in 40 per cent of the cases. The uric acid level in the serum of rats bearing AH 130 tumor rose after the administration of anticancer drugs. However, the level did not rise in patients with stomach cancer given with 0.2mg Mitomycin per kg; even in the cases where cancer cells had been proved to be sensitive to the agents by DiPaolo's method, an elevation of the level did not take place after cancer chemotherapy, except in one case treated with Ititromin.
Journal
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- The Tohoku Journal of Experimental Medicine
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The Tohoku Journal of Experimental Medicine 89 (3), 251-264, 1966
Tohoku University Medical Press
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Details 詳細情報について
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- CRID
- 1390001204242360320
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- NII Article ID
- 130003497690
- 40018682474
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- NII Book ID
- AA00863920
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- COI
- 1:CAS:528:DyaF28XltVagsb4%3D
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- ISSN
- 13493329
- 00408727
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- NDL BIB ID
- 8507514
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- PubMed
- 4290932
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed