Studies on Azeotropic Mixture of Fluoromar and Freon 113

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  • Inagaki Minoru
    Department of Anesthesiology, Tohoku University School of Medicine
  • Yusa Tsuneo
    Department of Anesthesiology, Tohoku University School of Medicine
  • Aoba Yuuko
    Department of Anesthesiology, Tohoku University School of Medicine
  • Iwatsuki Kenichi
    Department of Anesthesiology, Tohoku University School of Medicine

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Fluoromar is a useful anesthetic agent except that it is flammable in the concentrations necessary for clinical anesthesia. According to Krantz et al., the azeotropic mixture of Fluoromar and Freon 113 possesses the advantage of reducing the flammability of Fluoromar and more useful in clinical practice. The purpose of the present investigation is to evaluate the anesthetic action, the lower limit of flammability and the circulatory effects of the azeotropic mixture, by comparing with those of Fluoromar.<br> The results showed that the lower limit of flammability of the azeotropic mixture was 7.1-7.4 vols. % in oxygen, apparently higher as compared with that of Fluoromar, which was 4.0-4.2 vols. % in the same condition, but the flammability of Fluoromar itself was not reduced significantly by Freon 113. Although Freon 113 exhibited a little synergistic effect upon the anesthetic action of Fluoromar, it appeared not enough to lower the concentration of Fluoromar in the azeotropic mixture below its flammable limit. Moreover, the cardiovascular depression was found far greater with the azeotropic mixture than with Fluoromar. So far as the results are concerned, the azeotropic mixture of Fluoromar and Freon 113 seems to have little advantage over Fluoromar as an anesthetic agent.

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