Occasional Appearance of Diphosphopyridine Nucleotide in Urine of Patients with Progressive Muscular Dystrophy
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- Kondo Fumio
- Nishitaga National Sanatorium
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- Abe Eiji
- Nishitaga National Sanatorium
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- Ikeda Masao
- Nishitaga National Sanatorium
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- Mue Suetsugu
- Department of Biochemistry Tohoku University School of Medicine
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Urine analysis of patients with progressive muscular dystrophy (PMD) revealed that one of these patients excreted a considerable amount of diphos-phopy ridine nucleotide (DPN) in urine. DPN in urine was identified by column chromatography using Dowex 1×10 (formate type), paper chromato-graphy, absorption spectrum, and by absorbency changes after being reacted with potassium cyanide and with yeast alcohol dehydrogenase. DPN excretion in urine in some other PMD eases was evidenced by the alcohol dehydrogenase method. Numerous urine specimens from normal and diseased individuals were also examined for DPN, but urinary DPN could be demonstrated in no case other than those of PMD.<br> The significance of DPN excretion in PMD was discussed in view of the fact that DPN is an important coenzyme in cellular metabolism and that so far no report has appeared on the occurrence of appreciable amounts of DPN in human urine.
収録刊行物
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- The Tohoku Journal of Experimental Medicine
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The Tohoku Journal of Experimental Medicine 91 (2), 191-199, 1967
東北ジャーナル刊行会
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詳細情報 詳細情報について
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- CRID
- 1390001204242391936
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- NII論文ID
- 130003408627
- 40018682542
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- NII書誌ID
- AA00863920
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- COI
- 1:CAS:528:DyaF2sXktVWlt7c%3D
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- ISSN
- 13493329
- 00408727
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- NDL書誌ID
- 8507582
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- PubMed
- 4292997
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可