Transformation in vitro of the embryonal hamster brain by human adenovirus type 12

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  • Kusano Toshihisa
    The Microbiology Division, Research Institute for Tuberculosis, Leprosy and Cancer, Tohoku University
  • Yamane Isao
    The Microbiology Division, Research Institute for Tuberculosis, Leprosy and Cancer, Tohoku University

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  • Transformation <i>in vitro</i> of the Embryonal Hamster Brain Cells by Human Adenovirus Type 12

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The cells obtained from 15 to 19 day old embryonal brain tissues of random bred strains of golden hamsters (Mesocrisetus auratus) were inoculated with high titer adenovirus type 12 (Huie strain). In 20 days foci of transformed cells appeared in the cultures when inoculated with more than 106 TCID50 per ml of virus. They were circumscribed by the surrounding cells and remained adherent to one another. It was demonstrated that three of these foci had adenovirus type specific T antigens. Four cell lines obtained from each focus were examined for their tumor producing capacity. All the lines tested were highly malignant.

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