Effect of Medullo-adrenalectomy upon Urinary Excretion of Adrenaline and Noradrenaline in Cats

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  • Sakai Yasuharu
    Department of Physiology Nagasaki University School of Medicine

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Urine of cats was collected before and after medullo-adrenalectomy and was analyzed fluorimetrically for adrenaline and noradrenaline. Bilateral medullo-adrenalectomy was performed in two stages under sodium pentobarbital anesthesia. Urinary excretions of adrenaline and noradrenaline were not changed by unilateral medullo-adrenalectomy. After bilateral medullo-adrenalectomy, the excretion of adrenaline was reduced markedly, whereas that of noradrenaline was not changed. These results indicate that adrenaline excreted in urine is derived mainly from the adrenal medulla and, in part, from the other sources, while noradrenaline in urine comes mainly from extra-adrenal origins, presumably the endings of adrenergic nerve fibers.

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