Effect of Procaine, Calcium, Magnesium and Potassium on the Acetylcholine Release from the Sweat Nerve Endings in Human Skin
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- Wada Masao
- Physiological Laboratory Tohoku University School of Medicine
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- Sato Seiichi
- Physiological Laboratory Tohoku University School of Medicine
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- Koyama Wataru
- Physiological Laboratory Tohoku University School of Medicine
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- Hayashi Hiromu
- Physiological Laboratory Tohoku University School of Medicine
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- Hanawoka Juko
- Physiological Laboratory Tohoku University School of Medicine
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抄録
The effects of procaine, Ca, Mg and K on the release of transmitter from the cholinergic sweat nerve endings in the forearm skin were studied. Sweating was visualized by the iodine-starch method of Wada and Takagaki.<br> At a concentration of 10-7, intradermal injections of eserine did not produce a local sweating in a cool environment, but they became effective in eliciting sweat response on the injection wheals by entering a warm or hot environment. Local sweat responses to eserine in 10-6 and 10-5 were also intensified on exposure to heat.<br> Procaine in 10-4 inhibited the sweat responses to eserine very probably by affecting the acetylcholine release from the sweat nerve endings. It was found that Ca ions contained in Krebs solution are important in the process of the acetylcholine release and excessive Ca facilitates this release. In contrast, Mg and K ions present in Krebs solution were without any effect. But, when Mg was in excess relative to Ca, it was observed that Mg antagonized the effect of Ca. The antagonism between Mg and Ca was demonstrated also in the case of spontaneous thermoregulatory sweating. The effect of Ca on the acetylcholine release seems to be antagonized by Mg in a ratio of approximately 1:2 in molality.
収録刊行物
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- The Tohoku Journal of Experimental Medicine
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The Tohoku Journal of Experimental Medicine 95 (3), 297-311, 1968
東北ジャーナル刊行会
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詳細情報 詳細情報について
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- CRID
- 1390001204243117184
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- NII論文ID
- 130003497885
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- NII書誌ID
- AA00863920
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- COI
- 1:CAS:528:DyaF1cXkvFGjsb4%3D
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- ISSN
- 13493329
- 00408727
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- NDL書誌ID
- 8507755
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- PubMed
- 5707902
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可