Effects of nicotine and dimethylphenylpiperazinium on the S-A node activity of dogs in situ

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  • Effects of Nicotine and Dimethylphenylpiperazinium on the S-A Node Activity of Dogs <i>in situ</i>

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The perfusion of the sinus node artery in dogs in situ was performed. The selective administration of nicotine and DMPP into the sinus node artery induced a biphasic response, i.e., a negative chronotropic response followed by a positive one. Both compounds produced similar negative chronotropic responses, but positive responses were more markedly induced by DMPP than by nicotine.<br> These negative chronotropic responses were blocked by atropine, hexamethonium and tetrodotoxin. The positive response to nicotine was blocked by propranolol and tetrodotoxin. DMPP-induced positive chronotropic effect was blocked by propranolol but never by tetrodotoxin.<br> It is suggested that the positive chronotropic action of DMPP is different from that of nicotine on the sino-atrial node and is similar to that of tyramine.

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