Effect of dietary components on renal inorganic phosphate (Pi) excretion induced by a Pi-depleted diet

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  • Ohnishi Ritsuko
    Department of Molecular Nutrition, Institution of Health Biosciences, the University of Tokushima Graduate School
  • Segawa Hiroko
    Department of Molecular Nutrition, Institution of Health Biosciences, the University of Tokushima Graduate School
  • Ohmoto Tomoyo
    Department of Molecular Nutrition, Institution of Health Biosciences, the University of Tokushima Graduate School
  • Sasaki Shohei
    Department of Molecular Nutrition, Institution of Health Biosciences, the University of Tokushima Graduate School
  • Hanazaki Ai
    Department of Molecular Nutrition, Institution of Health Biosciences, the University of Tokushima Graduate School
  • Mori Ayaka
    Department of Molecular Nutrition, Institution of Health Biosciences, the University of Tokushima Graduate School
  • Ikuta Kayo
    Department of Molecular Nutrition, Institution of Health Biosciences, the University of Tokushima Graduate School
  • Furutani Junya
    Department of Molecular Nutrition, Institution of Health Biosciences, the University of Tokushima Graduate School
  • Kawakami Eri
    Department of Molecular Nutrition, Institution of Health Biosciences, the University of Tokushima Graduate School
  • Tatsumi Sawako
    Department of Molecular Nutrition, Institution of Health Biosciences, the University of Tokushima Graduate School
  • Hamada Yasuhiro
    Department of Therapeutic Nutrition, Institution of Health Biosciences, the University of Tokushima Graduate School
  • Miyamoto Ken-ichi
    Department of Molecular Nutrition, Institution of Health Biosciences, the University of Tokushima Graduate School

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説明

Dietary inorganic phosphate (Pi) is the most important factor in the regulation of renal Pi excretion. Recent studies suggest the presence of an enteric-renal signaling axis for dietary Pi as well as the existence of a mechanism by which the intestine detects changes in luminal Pi concentrations. The mechanisms of intestinal Pi sensing, however, are unknown. In the present study, we focused on Pi depletion signals and investigated the effects of dietary components on intestinal Pi sensing. After feeding rats experimental diets for 3 days, we investigated urinary Pi excretion and plasma biochemical parameters. Renal Pi excretion was suppressed in rats fed a low-Pi diet (0.02% Pi). Elimination of dietary calcium (Ca) completely blocked the suppression of Pi excretion, suggesting that the presence of Ca is essential for the Pi depletion signal. Furthermore, a minimum Ca content of more than 0.02% was necessary for the Pi depletion signal. Magnesium, lanthanum, and strontium, which are agonists of calcium sensing receptor, instead of Ca, reduced Pi excretion. Therefore, dietary Ca appears to be important for the Pi depletion-sensing mechanism in the gastrointestinal tract. In addition, the calcium sensing receptor may be involved in the Pi depletion signal. J. Med. Invest. 61: 162-170, February, 2014

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