Bonelike Apatite Coating on Skeleton of Poly(lactic acid) Composite Sponge
-
- Maeda Hirotaka
- Graduate School of Engineering, Nagoya Institute of Technology
-
- Kasuga Toshihiro
- Graduate School of Engineering, Nagoya Institute of Technology
-
- Nogami Masayuki
- Graduate School of Engineering, Nagoya Institute of Technology
この論文をさがす
説明
A novel sponge, coated with bonelike apatite (b-HA) on its skeleton surface, was prepared using a particle-leaching technique combined with a biomimetic processing. A powder mixture consisting of calcium carbonate/poly(lactic acid) composite (CCPC) and sucrose was hot-pressed and then the resulting compact was soaked in the simulated body fluid at 37°C. Within the first hour, the sucrose was completely dissolved out, resulting in the formation of large-sized pores in the compact, and subsequently, after 3 hours of soaking, b-HA formed on the skeleton consisting of CCPC. On the other hand, on a pore-free CCPC, the apatite started to form after 12∼18 hours. The induction period for b-HA formation on the skeleton of the CCPC sponge prepared using a particle-leaching technique is significantly shorter than that of the pore-free CCPC. The short period is suggested to originate from that a large amount of Ca2+ ion is rapidly supplied into the compartment space (pore) from the CCPC skeleton. The formed sponge has numerous, large pores of 450∼580 μm in diameter, which are connected with channels having a diameter in the range of 70∼120 μm, as well as a high porosity of 75%. Animal test using rats showed that the sponge has osteoconduction. The sponge is expected to be one of the promising candidates for osteoconducting fillers or tissue-engineering scaffolds.
収録刊行物
-
- MATERIALS TRANSACTIONS
-
MATERIALS TRANSACTIONS 45 (4), 989-993, 2004
公益社団法人 日本金属学会
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1390001204250187392
-
- NII論文ID
- 130004452412
- 10012905306
-
- NII書誌ID
- AA1151294X
-
- COI
- 1:CAS:528:DC%2BD2cXksVyht7s%3D
-
- ISSN
- 13475320
- 13459678
-
- NDL書誌ID
- 6926954
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
-
- 抄録ライセンスフラグ
- 使用不可