Determination of Nifuroxazide in Human Serum by Adsorptive Stripping Voltammetry.

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  • RADI A.
    Chemistry Department, Faculty of Science, Mansoura University
  • EL RIES M. A.
    National Organization for Drug Control and Research

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Abstract

The adsorption behavior of nifuroxazide on a hanging mercury drop electrode (HMDE) was critically examined using cyclic voltammetry and differential pulse techniques. The effect of different parameters on the accumulation behavior of the adsorbed species was tested. Thus, a sensitive stripping voltammetry procedure for the determination of nifuroxazide with an adsorptive accumulation on the surface of HMDE has been developed. Under optimal conditions a detection limit of 5×10-9 Mand a linear calibration graph in the range 2×10-8 - 1×10-7 M were obtained. The precision, expressed by the relative standard deviation, was 2.8% (n=10) at 1×10-7 M. The method was successfully applied for the analysis of nifuroxazide in serum.

Journal

  • Analytical Sciences

    Analytical Sciences 15 (4), 385-388, 1999

    The Japan Society for Analytical Chemistry

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