Determination of Cefadroxil by Sequential Injection with Spectrophotometric Detector
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- MAKCHIT Jirayu
- Department of Chemistry, Faculty of Science, Chiang Mai University
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- UPALEE Suphachock
- Department of Chemistry, Faculty of Science, Chiang Mai University
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- THONGPOON Chalermporn
- Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University
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- LIAWRUANGRATH Boonsom
- Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University
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- LIAWRUANGRATH Saisunee
- Department of Chemistry, Faculty of Science, Chiang Mai University
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A sequential injection analysis (SIA) spectrophotometric procedure for cefadroxil determination has been developed. The SIA instrumentation was modified to achieve the desired function and operations by using the software developed to interface the PC with the conventional SIA system. The method is based on the measurement of a red, water-soluble product formed by the reaction between cefadroxil and 4-aminoantipyrine in the presence of alkaline potassium hexacyanoferrate(III) at 510 nm. Optimum conditions for determining the drug were investigated. Beer's law was obeyed over the concentration ranges of 1 - 10 mg L-1 and 10 - 50 mg L-1 with a detection limit (3 σ) of 0.17 mg L-1 and a limit of quantification (10 σ) of 0.56 mg L-1. The relative standard deviations of 1.98% and 1.93% for 5 mg L-1 and 30 mg L-1 of the drug, respectively (n = 11) are obtained. The proposed method has been applied satisfactorily to the determination of cefadroxil in commercial pharmaceutical formulations with a sampling rate of 100 h-1. Results obtained were in good agreement with those obtained by the official HPLC method at the 95% confidence level.
収録刊行物
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- Analytical Sciences
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Analytical Sciences 22 (4), 591-597, 2006
社団法人 日本分析化学会
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詳細情報 詳細情報について
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- CRID
- 1390001204255495424
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- NII論文ID
- 10018123983
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- NII書誌ID
- AA10500785
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- ISSN
- 13482246
- 09106340
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- NDL書誌ID
- 7872031
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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