Flow Injection Spectrophotometric Determination of Tetracycline in a Pharmaceutical Preparation by Complexation with Aluminium(III)
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- LIAWRUANGRATH Saisunee
- Department of Chemistry, Faculty of Sciences, Chiang Mai University
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- LIAWRUANGRATH Boonsom
- Department of Pharmaceutical Chemistry, Faculty of Phamacy, Chiang Mai University
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- WATANESK Surasak
- Department of Chemistry, Faculty of Sciences, Chiang Mai University
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- RUENGSITAGOON Wirat
- Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Khon Kaen University
書誌事項
- タイトル別名
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- Flow Injection Spectrophotometric Determination of Tetracycline in a Pharmaceutical Preparation by Complexation with Aluminium 3
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説明
A rapid flow injection (FI) spectrophotometric procedure for tetracycline determination is described. It is based on the injection of a 100 µl sample solution containing tetracycline into merged streams of aluminium(III) chloride (0.01 mol l-1) and Tris-buffer in the presence of KCl (0.06 mol l-1), pH 7.0, with the same optimum flow rate of 3.2 ml min-1. A yellow Al(III)-tetracycline complex was monitored at 376 nm. The flow injection system and the experimental conditions were optimized by means of the univariate method. The procedure was applied to the determination of tetracycline in pharmaceutical preparations with a high sampling rate of at least 165 h-1. A high precision with a relative standard deviation was obtained less than 0.72 and 0.30% of 5.0 and 10 µg ml-1 (n = 11), respectively. The detection limit (3 σ) and the quantification limit (10 σ) were 0.07 and 0.72 mg l-1, respectively. There were no interference effects from traditional excipients in the dosage forms when the method was applied to pharmaceutical preparations. The matrix effect could be reduced by the standard addition method.
収録刊行物
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- Analytical Sciences
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Analytical Sciences 22 (1), 15-19, 2006
社団法人 日本分析化学会
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詳細情報 詳細情報について
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- CRID
- 1390001204255780352
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- NII論文ID
- 130004441137
- 10017165769
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- NII書誌ID
- AA10500785
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- COI
- 1:CAS:528:DC%2BD28XntVyjtA%3D%3D
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- ISSN
- 13482246
- 09106340
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- NDL書誌ID
- 7763287
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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- 抄録ライセンスフラグ
- 使用不可