Integration of Chemical and Biochemical Analysis Systems into a Glass Microchip.

DOI HANDLE PDF Web Site Web Site View 2 Remaining Hide 17 Citations 47 References Open Access
  • SATO Kiichi
    Department of Applied Chemistry, School of Engineering, The University of Tokyo
  • HIBARA Akihide
    Department of Applied Chemistry, School of Engineering, The University of Tokyo
  • TOKESHI Manabu
    Integrated Chemistry Project, Kanagawa Academy of Science and Technology (KAST)
  • HISAMOTO Hideaki
    Department of Applied Chemistry, School of Engineering, The University of Tokyo
  • KITAMORI Takehiko
    Department of Applied Chemistry, School of Engineering, The University of Tokyo Integrated Chemistry Project, Kanagawa Academy of Science and Technology (KAST)

Search this article

Abstract

This review focuses on the integration of chemical and biochemical analysis systems into glass microchips for general use. By combining multiphase laminar flow driven by pressure and micro unit operations, such as mixing, reaction, extraction and separation, continuous-flow chemical processing systems can be realized in the microchip format, while the application of electrophoresis-based chip technology is limited. The performances of several analysis systems were greatly improved by microchip integration because of some characteristics of microspace, i.e., a large specific interface area, a short molecular diffusion time, a small heat capacity and so on. By applying these concepts, several different analysis systems, i.e., wet analysis of cobalt ion, multi-ion sensor, immunoassay, and cellular analysis, were successfully integrated on a microchip. These microchip technologies are promising for meeting the future demands of high-throughput chemical processing.

Journal

  • Analytical Sciences

    Analytical Sciences 19 (1), 15-22, 2003

    The Japan Society for Analytical Chemistry

Citations (17)*help

See more

References(47)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top