Rapid Determination of Benzene Metabolites Phenol and p-Cresol in the Urine of Petrol Station Workers by Gas Chromatography.

KHOSCHSORUR GholamAli, PETEK Walter

doi:10.2116/analsci.16.589

Rapid Determination of Benzene Metabolites Phenol and p-Cresol in the Urine of Petrol Station Workers by Gas Chromatography.

DOI PDF Web Site Web Site Web Site 被引用文献1件参考文献25件

KHOSCHSORUR GholamAli

University Surgical Clinic, Department of Clinical Chemistry and Laboratory Medicine
PETEK Walter

University Surgical Clinic, Department of Clinical Chemistry and Laboratory Medicine

この論文をさがす

抄録

The determination of phenol and p-cresol in urine has been suggested as a suitable biomarker for the monitoring of benzene exposure of pump workers employed in petrol stations. A method for efficiently extracting a wide variety of drugs from urine for toxicological analysis by gas chromatography is presented. The sensitivity of the method is sufficient to monitor normal levels of phenol and p-cresol after exposure to benzene vapors. The detection limit of the method is low enough to measure urinary phenol and p-cresol at a concentration of 0.1 mg/l. The overall recoveries of urinary phenol and p-cresol relative to the internal standard, DPA, ranged between 95 and 96.5%. Our gas chromatographic method is a rapid, precise and economical one suitable to measure the metabolite benzene also in routine monitoring of phenol and p-cresol.