Resonance Rayleigh-Scattering Method for the Determination of Sildenafil Citrate in a Pharmaceutical Formulation Using Evans Blue

DOI PDF Web Site Web Site Web Site 被引用文献1件 参考文献56件
  • LIU Shao-Pu
    School of Chemistry and Chemical Engineering, Southwest China Normal University
  • FAN Li
    School of Chemistry and Chemical Engineering, Southwest China Normal University
  • HU Xiao-Li
    School of Chemistry and Chemical Engineering, Southwest China Normal University
  • LIU Zhong-Fang
    School of Chemistry and Chemical Engineering, Southwest China Normal University
  • LI Shan
    School of Chemistry and Chemical Engineering, Southwest China Normal University

この論文をさがす

抄録

A highly sensitive resonance Rayleigh-scattering (RRS) method for the determination of sildenafil citrate has been developed, based on the fact that sildenafil (Sild) reacted with Evans Blue (EB) to form an ion-association complex in pH 1.1 - 4.6 aqueous solution. This resulted in a significant enhancement of the RRS intensity, and a new spectrum appeared. The wavelength of the maximum RRS was at 365 nm, and other scattering peaks were at 400, 442, 470 and 534 nm, respectively. The intensity of RRS was directly proportional to the concentration of Sild in the range 0 - 11.5 µg ml-1, and the detection limit for Sild (3 σ) was 30.3 ng ml-1. The composition of the ion-association complex was Sild:EB = 1:1, as established by Job's method. The method had good selectivity and could be applied to the determination of Sild in the aqueous phase without using organic solvent extraction. The method was simple and rapid. In addition, the reaction mechanism and the reason for RRS enhancement were considered.

収録刊行物

  • Analytical Sciences

    Analytical Sciences 22 (6), 819-823, 2006

    社団法人 日本分析化学会

被引用文献 (1)*注記

もっと見る

参考文献 (56)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ