2,4-Toluene Diamines—Their Carcinogenicity, Biodegradation, Analytical Techniques and an Approach towards Development of Biosensors

SHANMUGAM Kumaran, SUBRAHMANYAM Sreenath, TARAKAD Subramanian V., KODANDAPANI Narendran, STANLY D’Souza F.

doi:10.2116/analsci.17.1369

2,4-Toluene Diamines—Their Carcinogenicity, Biodegradation, Analytical Techniques and an Approach towards Development of Biosensors

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SHANMUGAM Kumaran

Department of Chemical Engineering, Anna University
SUBRAHMANYAM Sreenath

Department of Chemical Engineering, Anna University
TARAKAD Subramanian V.

Department of Chemical Engineering, Anna University
KODANDAPANI Narendran

Center for Ecological Sciences, Indian Institute of Science
STANLY D’Souza F.

Nuclear Agriculture and Biotechnology Division, Bhabha Atomic Research Centre

書誌事項

タイトル別名

2,4-Toluene Diamines. Their Carcinogenicity, Biodegradation, Analytical Techniques and an Approach towards Development of Biosensors.

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抄録

2,4-Toluene diamine (TDA), a class A carcinogen, is a major raw material for the production of toluene diisocyanate (TDI), which is one of the precursors for the production of polyurethane foams (PU). This review deals with 2,4-toluene diamine’s (TDA) carcinogenicity, analytical techniques, biodegradation and use as a biosensor for biogenic and synthetic amines, emphasizing various carcinogenicity studies by 2,4-TDA on animals and humans. This review reports some publications of the analysis of body fluid samples of workers from a PU producing factory for presence of TDA and TDI, since TDI gets absorbed into the worker’s body, getting metabolized into TDA. Biodegradations of 2,4-TDA by various researchers are reported and also our own research experience with biodegradation of 2,4-TDA using Aspergillus nidulans isolated from soil site at a polyurethane foam dumping site have been discussed in this review. Biosensors for various biogenic and synthetic amines are discussed.