Flow-Injection Spectrophotometric Determination of Novalgin in Pharmaceuticals Using Micellar Medium
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- WEINERT Patrícia Los
- Instituto de Química-UNESP
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- FERNANDES João Roberto
- Departamento de Química-FC/UNESP
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- PEZZA Leonardo
- Instituto de Química-UNESP
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- PEZZA Helena Redigolo
- Instituto de Química-UNESP
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A sensitive flow-injection (FI) procedure with spectrophotometric detection in a micellar medium is proposed for the determination of novalgin. The method is based on the instantaneous formation of a red-orange product (λmax = 510 nm) after the reaction between novalgin and p-dimethylaminocinnamaldehyde (p-DAC) in a dilute acid medium. The sensitivity of this reaction was increased by a factor of 5.6 in the presence of sodium dodecyl sulfate (SDS). Experimental design methodologies were used to optimize the chemical and FI variables. The calibration curve was linear in the range of 1.45 × 10-6 to 2.90 × 10-5 mol L-1 with an excellent correlation coefficient (r = 0.9999). The detection limit was 1.31 × 10-7 mol L-1 (n = 20, RSD = 2.0%). No interferences were observed from the common excipients. The results obtained by the proposed method were favorably compared with those given by the iodometric reference method at 95% confidence level.
収録刊行物
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- Analytical Sciences
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Analytical Sciences 23 (12), 1383-1389, 2007
社団法人 日本分析化学会
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詳細情報 詳細情報について
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- CRID
- 1390001204257058048
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- NII論文ID
- 10020012645
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- NII書誌ID
- AA10500785
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- ISSN
- 13482246
- 09106340
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- NDL書誌ID
- 9286647
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
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- 使用不可