Attachment of DNA to the Carbon Fiber Microelectrode via Gold Nanoparticles for Simultaneous Determination of Dopamine and Serotonin

LU Liping, WANG Shuqing, LIN Xiangqin

doi:10.2116/analsci.20.1131

Attachment of DNA to the Carbon Fiber Microelectrode via Gold Nanoparticles for Simultaneous Determination of Dopamine and Serotonin

DOI PDF Web Site Web Site Web Site PubMed ほか1件をすべて表示一部だけ表示参考文献56件

LU Liping

Department of Chemistry, University of Science and Technology of China
WANG Shuqing

Department of Chemistry, University of Science and Technology of China
LIN Xiangqin

Department of Chemistry, University of Science and Technology of China

この論文をさがす

抄録

A novel biochemical sensor was fabricated on a carbon fiber microelectrode, which consisted of an inner layer of electrodeposited gold nanoparticles, as a nano-array electrode, and an outer layer of electrodeposited calf thymus ds-DNA at +1.5 V vs. SCE. This modified electrode was characterized by X-ray photoelectron spectroscopy, scanning electron microscope, atomic force microscopy, cyclic voltammetry and differential pulse voltammetry (DPV). It was found that this electrochemical sensor exhibits a strong catalytic activity toward the oxidation of dopamine (DA), serotonin (5-HT) and ascorbic acid (AA), as a result of resolving the anodic voltammetric peaks of DA, 5-HT and AA into three welldefined peaks. Simutaneous DPV determination of DA and 5-HT can be achieved in the presence of 2000-fold AA. The modified electrode shows good sensitivity, selectivity and stability.