PVC Matrix Membrane Sensor for Potentiometric Determination of Cetylpyridinium Chloride.

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  • MOSTAFA Gamal A. E.
    Microanalytical Laboratory, Applied Organic Chemistry Department, National Research Center

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Abstract

A novel cetylpyridinium chloride-selective membrane sensor consisting of cetylpyridinium-ferric thiocyanate ion pairs dispersed in a PVC matrix placticized with dioctylphthalate is described. The electrode shows a stable, near-Nernstian response for 1 × 10-3 - 1 × 10-6 mol l-1 cetylpyridinium chloride (CPC) at 25°C over the pH range 1 - 6 with a cationic slope of 57.5 ± 0.4. The lower detection limit is 8 × 10-7 mol l-1 and the response time is 30 - 60 s. Selectivity coefficients for CPC relative to a number of interfering substances were investigated. There is negligible interference from many cations, anions and pharmaceutical excipients; however, cetyltrimethylammonim bromide (CTMAB) interfered significantly. The determination of 0.5 - 350 µg/ml of CPC in aqueous solutions shows an average recovery of 98.5% and a mean relative standard deviation of 1.6% at 56.0 µg/ml. The direct determination of CPC in Ezafluor mouthwash gave results that compare favorably with those obtained by the British Pharmacopoeia method. Precipitation titrations involving CPC as titrant are monitored with a CP sensor. The CP electrode has been utilized as an end point indicator electrode for the determination of anionic surfactants in some commercial detergents.

Journal

  • Analytical Sciences

    Analytical Sciences 17 (9), 1043-1047, 2001

    The Japan Society for Analytical Chemistry

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