Sensitive Analysis of Blonanserin, a Novel Antipsychotic Agent, in Human Plasma by Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry
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- OGAWA Tadashi
- Department of Legal Medicine, Aichi Medical University School of Medicine
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- HATTORI Hideki
- Department of Legal Medicine, Aichi Medical University School of Medicine
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- KANEKO Rina
- Department of Legal Medicine and Bioethics, Nagoya University Graduate School of Medicine
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- ITO Kenjiro
- Department of Legal Medicine, Aichi Medical University School of Medicine
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- IWAI Masayo
- Department of Legal Medicine, Aichi Medical University School of Medicine
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- MIZUTANI Yoko
- Department of Legal Medicine, Aichi Medical University School of Medicine
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- ARINOBU Tetsuya
- Department of Chemistry, Aichi Medical University School of Medicine
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- ISHII Akira
- Department of Legal Medicine and Bioethics, Nagoya University Graduate School of Medicine
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- SUZUKI Osamu
- Department of Legal Medicine, Hamamatsu University School of Medicine
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- SENO Hiroshi
- Department of Legal Medicine, Aichi Medical University School of Medicine
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Description
A rapid and sensitive method for analysis of blonanserin in human plasma by ultra-performance liquid chromatography-tandem mass spectrometry is presented. After pretreatment of a plasma sample by solid-phase extraction, blonanserin was analyzed by the system with a C18 column. This method gave satisfactory recovery rates, reproducibility, and good linearity of calibration curve in the range of 0.01 – 10.0 ng/mL for quality control samples spiked with blonanserin. The detection limit was as low as 1 pg/mL. This method seems very useful in forensic and clinical toxicology and pharmacokinetic studies.
Journal
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- Analytical Sciences
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Analytical Sciences 26 (10), 1099-1102, 2010
The Japan Society for Analytical Chemistry
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Details 詳細情報について
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- CRID
- 1390001204258911360
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- NII Article ID
- 10026785897
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- NII Book ID
- AA10500785
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- ISSN
- 13482246
- 09106340
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- NDL BIB ID
- 10838119
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- Web Site
- http://id.ndl.go.jp/bib/10838119
- https://ndlsearch.ndl.go.jp/books/R000000004-I10838119
- https://link.springer.com/content/pdf/10.2116/analsci.26.1099.pdf
- https://link.springer.com/article/10.2116/analsci.26.1099/fulltext.html
- http://www.jstage.jst.go.jp/article/analsci/26/10/26_10_1099/_pdf
- https://search.jamas.or.jp/link/ui/2011164322
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed