A Quantitative Determination of Magnetic Nanoparticle Separation Using On-Off Field Operation of Quadrupole Magnetic Field-Flow Fractionation (QMgFFF)

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  • ORITA Toru
    Division of Chemistry for Materials, Graduate School of Engineering, Mie University Taiyo Kagaku Co., Ltd. Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic
  • MOORE Lee R.
    Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic
  • JOSHI Powrnima
    Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic
  • TOMITA Masahiro
    Division of Chemistry for Materials, Graduate School of Engineering, Mie University
  • HORIUCHI Takashi
    Division of Chemistry for Materials, Graduate School of Engineering, Mie University
  • ZBOROWSKI Maciej
    Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic

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Quadrupole Magnetic Field-Flow Fractionation (QMgFFF) is a technique for characterization of sub-micrometer magnetic particles based on their retention in the magnetic field from flowing suspensions. Different magnetic field strengths and volumetric flow rates were tested using on-off field application and two commercial nanoparticle preparations that significantly differed in their retention parameter, λ (by nearly 8-fold). The fractograms showed a regular pattern of higher retention (98.6% v. 53.3%) for the larger particle (200 nm v. 90 nm) at the higher flow rate (0.05 mL/min v. 0.01 mL/min) at the highest magnetic field (0.52 T), as expected because of its lower retention parameter. The significance of this approach is a demonstration of a system that is simpler in operation than a programmed field QMgFFF in applications to particle mixtures consisting of two distinct particle fractions. This approach could be useful for detection of unwanted particulate contaminants, especially important in industrial and biomedical applications.

収録刊行物

  • Analytical Sciences

    Analytical Sciences 29 (7), 761-764, 2013

    社団法人 日本分析化学会

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