Dark Field Microscopic Sensitive Detection of Amyloid Fibrils Using Gold Nanoparticles Modified with Antibody
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- BU Tong
- Department of Advanced Materials Science, School of Frontier Sciences, The University of Tokyo Bioengineering Laboratory, RIKEN Institute
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- ZAKO Tamotsu
- Bioengineering Laboratory, RIKEN Institute
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- MAEDA Mizuo
- Department of Advanced Materials Science, School of Frontier Sciences, The University of Tokyo Bioengineering Laboratory, RIKEN Institute
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Dark field microscopy (DFM) was employed to detect amyloid β (Aβ) fibrils-induced gold nanoparticle (AuNP) aggregation at the single-particle level, with a detection limit of 40 pM fibrils. The sensitivity of this method is higher than that of the current fibril-specific detection method using probe dye, such as thioflavin T, for which sub-μM level of fibrils are necessary. This study further proved the potential application of DFM in the analytical methods based on AuNP aggregation.
収録刊行物
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- Analytical Sciences
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Analytical Sciences 32 (3), 307-311, 2016
社団法人 日本分析化学会
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詳細情報 詳細情報について
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- CRID
- 1390001204259149056
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- NII論文ID
- 130005131631
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- NII書誌ID
- AA10500785
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- ISSN
- 13482246
- 09106340
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- NDL書誌ID
- 027203996
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- PubMed
- 26960610
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- Web Site
- http://id.ndl.go.jp/bib/027203996
- https://ndlsearch.ndl.go.jp/books/R000000004-I027203996
- https://link.springer.com/content/pdf/10.2116/analsci.32.307.pdf
- https://link.springer.com/article/10.2116/analsci.32.307/fulltext.html
- https://www.jstage.jst.go.jp/article/analsci/32/3/32_307/_pdf
- https://search.jamas.or.jp/link/ui/2016313316
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- 本文言語コード
- en
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- JaLC
- NDL
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- PubMed
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