Polytetrafluorethylene Film-Based Liquid-Three Phase Micro Extraction Coupled with Differential Pulse Voltammetry for The Determination of Atorvastatin Calcium

DOI PDF Web Site Web Site Web Site View 1 Remaining Hide 72 References

Search this article

Description

In this paper, we describe a new combination method based on polytetrafluorethylene (PTFE) film-based liquid three-phase micro extraction coupled with differential pulse voltammetry (DPV) for the micro extraction and quantification of atorvastatin calcium (ATC) at the ultra-trace level. Different factors affecting the liquid-three phases micro extraction of atorvastatin calcium, including organic solvent, pH of the donor and acceptor phases, concentration of salt, extraction time, stirring rate and electrochemical factors, were investigated, and the optimal extraction conditions were established. The final stable signal was achieved after a 50 min extraction time, which was used for analytical applications. An enrichment factor of 21 was achieved, and the relative standard deviation (RSD) of the method was 4.5% (n = 4). Differential pulse voltammetry exhibited two wide linear dynamic ranges of 20.0 – 1000.0 pmol L−1 and 0.001 – 11.0 μmol L−1 of ATC. The detection limit was found to be 8.1 pmol L−1 ATC. Finally, the proposed method was used as a new combination method for the determination of atorvastatin calcium in real samples, such as human urine and plasma.

Journal

  • Analytical Sciences

    Analytical Sciences 29 (3), 303-309, 2013

    The Japan Society for Analytical Chemistry

References(72)*help

See more

Details 詳細情報について

Report a problem

Back to top