The Halogen Bond between Amantadine and Iodine and Its Application in the Determination of Amantadine Hydrochloride in Pharmaceuticals

DOI PDF Web Site Web Site Web Site ほか1件をすべて表示 一部だけ表示 参考文献23件

この論文をさがす

説明

It is proposed that molecular iodine as a donor could form halogen bonding complexes with amantadine (AMD) and amantadine hydrochloride (AMD-HCl) in chloroform and the resultant charge transfer bands (CT band) would be located at 259 and 253 nm, respectively. The halogen bonding interaction was explored by UV absorption, Raman and X-ray crystallography, and a new bonding model named N+···Nlep bond in crystal was observed. The halogen bonding complexes were utilized in the development of simple and accurate spectrophotometry for the analysis of AMD/AMD-HCl. Compared with the traditional method based on the absorption of I3− at 290 and 365 nm, the new proposed spectrometry based on the CT band of halogen bonding complex was more sensitive and selective for the detection of AMD/AMD-HCl. Linear relationships with good correlation coefficients (>0.9994) were obtained between the absorbance and the AMD/AMD-HCl concentration in the range of 10 – 180 μg mL−1 for AMD-HCl and 0.2 – 13 μg mL−1 for AMD. The limit of detection (LOD) was 2.23 μg mL−1 and limit of quantification (LOQ) was 7.45 μg mL−1 for AMD-HCl. And because of the stronger bond constant between AMD and iodine than AMD-HCl, the method is more sensitive for AMD; the LOD was 0.02 μg mL−1 and LOQ was 0.08 μg mL−1 which was 100 times lower than that of AMD-HCl.

収録刊行物

  • Analytical Sciences

    Analytical Sciences 30 (3), 365-370, 2014

    社団法人 日本分析化学会

参考文献 (23)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ