Application of a New Iridium Complex as a Chemiluminescence Reagent for the Determination of Tryptophan

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  • WU Fanghui
    School of Chemistry and Chemical Engineering, Institution of Molecular Engineering and Applied Chemistry, Anhui University of Technology
  • TONG Bihai
    School of Chemistry and Chemical Engineering, Institution of Molecular Engineering and Applied Chemistry, Anhui University of Technology
  • ZHANG Qianfeng
    School of Chemistry and Chemical Engineering, Institution of Molecular Engineering and Applied Chemistry, Anhui University of Technology

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抄録

It was found that a novel iridium complex, [(dpci)2Ir(bvbbi)](PF6) (dpci = 3,4-diphenylcinnoline, bvbbi = N,N′-bivinyester-1H,1′H-[2,2′] bibenzimidazole), with Ce(IV) in the presence of sodium sulfite can induce a great chemiluminescence (CL) emission. More importantly, a rapid and sensitive CL method for the determination of tryptophan coupled with a flow-injection analysis (FIA) technique has been developed based on the inhibition effect of the tryptophan to the CL emission of [(dpci)2Ir(bvbbi)](PF6)-Ce(IV)-SO32− system. Under the optimum conditions, the decreased CL intensity is proportional with the concentration of tryptophan in the range of 5.0 × 10−7 to 2.0 × 10−5 mol L−1, and the detection limit is 8.2 × 10−8 mol L−1 (3σ). The relative standard deviation (RSD) for 11 parallel measurements of 1.0 × 10−5 mol L−1 tryptophan is 2.7%. The proposed method has been applied successfully for the determination of tryptophan in its pharmaceutical formulations. Moreover, the possible inhibition mechanism of tryptophan on [(dpci)2Ir(bvbbi)](PF6)-Ce(IV)-SO32− CL system was briefly discussed.

収録刊行物

  • Analytical Sciences

    Analytical Sciences 27 (5), 529-, 2011

    社団法人 日本分析化学会

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